Lean Big Data integration in systems biology and systems pharmacology
نویسندگان
چکیده
منابع مشابه
Harnessing Big Data for Systems Pharmacology.
Systems pharmacology aims to holistically understand mechanisms of drug actions to support drug discovery and clinical practice. Systems pharmacology modeling (SPM) is data driven. It integrates an exponentially growing amount of data at multiple scales (genetic, molecular, cellular, organismal, and environmental). The goal of SPM is to develop mechanistic or predictive multiscale models that a...
متن کاملSystems biology and pharmacology.
Drug action depends not only on the direct consequences of the interaction between the drug and its target but also on other consequences within the complex physiological system that is the human body. The National Institute of General Medical Sciences (NIGMS) has brought together investigators from the emerging field of systems biology with pharmacologists to explore possible avenues for utili...
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Science is going through two rapidly changing phenomena: one is the increasing capabilities of the computers and software tools from terabytes to petabytes and beyond, and the other is the advancement in high-throughput molecular biology producing piles of data related to genomes, transcriptomes, proteomes, metabolomes, interactomes, and so on. Biology has become a data intensive science and as...
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Different experimental technologies measure different aspects of a system and to differing depth and breadth. High-throughput assays have inherently high false-positive and false-negative rates. Moreover, each technology includes systematic biases of a different nature. These differences make network reconstruction from multiple data sets difficult and error-prone. Additionally, because of the ...
متن کاملSystems Biology: The Big Picture
Microarray studies are capable of providing data for temporal gene expression patterns of thousands of genes simultaneously, comprising rich but cryptic information about transcriptional control. However available methods are still not adequate in extraction of useful information about transcriptional regulation from these data. This study presents a dynamic model of gene expression which allow...
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ژورنال
عنوان ژورنال: Trends in Pharmacological Sciences
سال: 2014
ISSN: 0165-6147
DOI: 10.1016/j.tips.2014.07.001